Citric Acid → HCID 131728835, compound

HRID 548514Notes

Reaction equation

[CH3:1][CH2:2][CH2:3][O:4][C:5]([C:18]([O:20][CH:21]1[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]1)=[O:19])([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1.[ClH:28].C(O)(=O)CC(CC(O)=O)(C(O)=O)O.CCCO[C:46]([C:59]([O:61][CH:62]1CCN(C)CC1)=[O:60])([C:53]1C=CC=CC=1)[C:47]1C=CC=CC=1>>[CH3:1][CH2:2][CH2:3][O:4][C:5]([C:18]([O:20][CH:21]1[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]1)=[O:19])([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1.[ClH:28].[CH3:53][C:46]([C:59]([O:61][CH3:62])=[O:60])=[CH2:47]

Participants

Reactant 3

HCID 311Citric Acid2×

HCID 4942Propiverine

HCID 441412Propiverine hydrochloride

Product 1

HCID 131728835HCID 131728835, compound

Procedure

Before filling into hard gelatine capsules, 2500 g of the thus obtained lacquered active agent pellets were screened under addition of 15 g microfine talc. The particle size fraction of 0.7 mm to 1.25 mm (2450 g, corresponding to 98.0% of the theoretical amount) has a content of 18.5% of propiverine-hydrochloride as determined according to Example 6. The content of citric acid was determined by means of the titration as described in Example 6 to be 49%. Thus the result is a molar ratio of propiverine to citric acid of 1:5.6, which is in the typical range.

Sources & evidence

ORD record: ord-d3f0b0b818b94055aa899fc8eb41f600
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943176B2

Reaction notes

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