Acetone → HCID 57581230, compound

HRID 548548Notes

Reaction equation

HRID 548548 reaction equation
[CH3:1][O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1[CH3:13].C([O-])([O-])=O.[K+].[K+].[CH3:21][C:22]([CH3:24])=O>>[CH3:1][O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:24][C:22]#[CH:21])=[CH:8][C:7]=1[CH3:13]

Participants

4

Reactant 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 23549552Methyl 2-(4-hydroxy-2-methylphenoxy)acetate

Product 1

HCID 57581230HCID 57581230, compound

Procedure

To a solution of (4-hydroxy-2-methyl-phenoxy)-acetic acid methyl ester (5.1 g, 25.8 mmol) and K2CO3 (7.1 g, 51.5 mmol) in acetone (85 ml) was added propagylbromide (3.1 g, 25.7 mmol) at room temperature. The reaction mixture was stirred at room temperature for 2 days, and then filtered and evaporated in vacuo. The residue was purified on column chromatography using methylene chloride as eluent to give the title compound in 6.0 (100%) yield.

Workup

  1. filtrationfiltered
  2. customevaporated in vacuo
  3. customThe residue was purified on column chromatography

Sources & evidence

ORD record
ord-78d19b0d8dab4bc7b0230d2effd67452
Source dataset
uspto-grants-2011_05
Patent number
US07943612B2

Reaction notes

Loading…