反应详情

2-(2,5-Dimethylpyrrol-1-yl)phenylacetonitrile (15 mmol) and diethyl oxalate (4.38 g, 30 mml) were sequentially added neat washing with ethanol (15 mL) to a solution of sodium tert-butoxide (1.73 g, 18 mmol) in ethanol (15 mL). The reaction mixture was heated at reflux under a nitrogen atmosphere for 4.5 hours to provide a solution of ethyl 3-cyano-3-[2-(2,5-dimethylpyrrol-1-yl)phenyl]-2-oxopropionate in ethanol.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux under a nitrogen atmosphere for 4.5 hours