Phosphorus oxychloride → HCID 86630217, compound

HRID 548597Notes

Reaction equation

HRID 548597 reaction equation
[NH2:1][C:2]1[N:3]([CH2:16][CH2:17][CH3:18])[N:4]=[C:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH:7][C:6]2=O.P(Cl)(Cl)([Cl:21])=O>C(OCC)C>[Cl:21][C:6]1[C:5]2=[N:4][N:3]([CH2:16][CH2:17][CH3:18])[C:2]([NH2:1])=[C:14]2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 67203666HCID 67203666, compound

Product 1

HCID 86630217HCID 86630217, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 1-amino-2-propyl-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one (86 mg, 0.36 mmol) in phosphorus oxychloride (3 mL) was heated at 100° C. for 45 minutes and then allowed to cool to ambient temperature. The reaction mixture was diluted with diethyl ether (10 mL). A solid was isolated by filtration, rinsed with diethyl ether, and dried to provide 4-chloro-2-propyl-2H-pyrazolo[3,4-c]quinolin-1-amine.

Workup

  1. customA solid was isolated by filtration
  2. washrinsed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-16bb526e9e0b46e6983986511580ed5c
Source dataset
uspto-grants-2011_05
Patent number
US07943610B2

Reaction notes

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