反应详情

To a solution of 8-chloro-3-(2,4-difluorophenyl)imidazo[1,5-a]pyrazine (Step C, 200 mg) in methanol, at 0° C. and under a nitrogen atmosphere was added palladium on carbon (75 mgs, 10 wt % Pd) and the contents hydrogenated at 50 psi for 20 hours. The reaction mixture was filtered and the filter cake washed with methanol (2×10 mL). The filtrate was concentrated under reduced pressure to yield a solid d (175 mgs) that was used as such for the subsequent step without further purification.

1. filtrationThe reaction mixture was filtered
2. washthe filter cake washed with methanol (2×10 mL)
3. concentrationThe filtrate was concentrated under reduced pressure
4. customto yield a solid d (175 mgs) that
5. customwithout further purification