8-Chloro-3-(2,4-difluorophenyl)imidazo[1,5-a]pyrazine → 3-(2,4-Difluorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-A]pyrazine

Participants

Reaction Steps

To a solution of 8-chloro-3-(2,4-difluorophenyl)imidazo[1,5-a]pyrazine (Step C, 200 mg) in methanol, at 0° C. and under a nitrogen atmosphere was added palladium on carbon (75 mgs, 10 wt % Pd) and the contents hydrogenated at 50 psi for 20 hours. The reaction mixture was filtered and the filter cake washed with methanol (2×10 mL). The filtrate was concentrated under reduced pressure to yield a solid d (175 mgs) that was used as such for the subsequent step without further purification.

Provenance & Evidence