反应详情

DIPEA (2.45 mL, 14.0 mmol) and tert-butyldimethylsilyl chloride (1.51 g, 10.0 mmol) were added to a solution of 2-(methylamino)ethanol (751 mg, 10.0 mmol) in dry DCM (25 mL) under argon and the reaction mixture allowed to stir at RT for 16 hours. Diethyl ether (50 mL) and water (50 mL) were added to the reaction mixture and the aqueous phase was extracted with diethyl ether (3×30 mL). The combined extracts were dried (MgSO4), filtered and evaporated to give a pale yellow oil which was dried under high vacuum to give the title compound (1.91 g).

1. extractionthe aqueous phase was extracted with diethyl ether (3×30 mL)
2. dry with materialThe combined extracts were dried (MgSO4)
3. filtrationfiltered
4. customevaporated
5. customto give a pale yellow oil which
6. customwas dried under high vacuum