反应详情

A solution of 1,1-dimethylethyl 3-[({3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate (23 g, 47.8 mmol) in THF (140 mL) and ethanol (140 mL) was evacuated and purged with nitrogen (×3). 10% Palladium on carbon (2.3 g; 10% w/w) was added and reaction mixture was evacuated and finally purged with hydrogen gas. The reaction mixture was left to stir at RT under a hydrogen balloon for 16 hours. The palladium on carbon was filtered through diatomaceous earth and the filtrate concentrated in vacuo to give a white foam (18 g).

1. custompurged with nitrogen (×3)
2. addition10% Palladium on carbon (2.3 g; 10% w/w) was added
3. customreaction mixture
4. customwas evacuated
5. customfinally purged with hydrogen gas
6. waitThe reaction mixture was left
7. filtrationThe palladium on carbon was filtered through diatomaceous earth
8. concentrationthe filtrate concentrated in vacuo