反应详情

As described for example 12, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (200 mg, 0.64 mmol) was converted, using 2-amino-2-methyl-propanol instead of ethanolamine, to the title compound (SiO2, heptane:ethyl acetate=95:5 to 50:50, 202 mg, 82%) which was obtained as a white foam. MS: m/e=383.3 [M+H]+.