反应详情

3-Iodo-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine (example 15a) (200 mg, 0.5 mmol) was dissolved in a solution of ammonia in methanol (7 M, 3 mL). After addition of copper(I) bromide (88 mg, 0.6 mmol) the mixture was stirred for 16 h at room temperature. The precipitate was filtered and the organic phase was adsorbed on silica. Chromatography (SiO2, dichloromethane:methanol=100:0 to 95:5) afforded the title compound (66 mg, 46%) as a light yellow solid. MS: m/e=283.1 [M+H]+.

1. filtrationThe precipitate was filtered