反应详情

A solution of N-acetyl-N-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-yl]-acetamide (70 mg, 0.19 mmol) in methanol (2 mL) was treated with sodium bicarbonate (1 spatula) and stirred at room temperature for 16 h. The solvent was evaporated and the residue was extracted (dichloromethane/water). The organic phase was dried over sodium sulfate and concentrated. Crystallization of the residue from diisopropylether afforded the title compound as a light brown solid (40 mg, 65%). MS: m/e=325.4 [M+H]+.

1. customThe solvent was evaporated
2. extractionthe residue was extracted (dichloromethane/water)
3. dry with materialThe organic phase was dried over sodium sulfate
4. concentrationconcentrated
5. customCrystallization of the residue from diisopropylether