Isobutyryl chloride → HCID 42629533, compound

HRID 548822Notes

Reaction equation

HRID 548822 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:20]=[N:19][C:18]([NH2:21])=[CH:17][CH:16]=1.[C:22](Cl)(=[O:26])[CH:23]([CH3:25])[CH3:24]>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:20]=[N:19][C:18]([NH:21][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 62325Isobutyryl chlorideHCID 426297716-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine

Product 1

HCID 42629533HCID 42629533, compoundYield 72%

Procedure

As described for example 18, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine (200 mg, 0.7 mmol) was converted, using isobutyryl chloride instead of methoxyacetyl chloride, to the title compound (180 mg, 72%) which was obtained as a white solid. MS: m/e=353.2 [M+H]−.

Sources & evidence

ORD record
ord-ebe72b630ad74838989aa6dac04a88aa
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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