Methyl chloroglyoxylate → HCID 42630377, compound

HRID 548830Notes

Reaction equation

HRID 548830 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:20]=[N:19][C:18]([NH2:21])=[CH:17][CH:16]=1.[CH3:22][O:23][C:24](=[O:28])[C:25](Cl)=[O:26]>>[CH3:22][O:23][C:24](=[O:28])[C:25]([NH:21][C:18]1[N:19]=[N:20][C:15]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)=[N:5][O:6][C:2]=2[CH3:1])=[CH:16][CH:17]=1)=[O:26]

Participants

3

Reactant 2

HCID 79846Methyl chloroglyoxylateHCID 426297716-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine

Product 1

HCID 42630377HCID 42630377, compoundYield 44%

Procedure

As described for example 18, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine (200 mg, 0.7 mmol) was converted, using chloro-oxo-acetic acid methyl ester instead of methoxyacetyl chloride, to the title compound (88 mg, 44%) which was obtained as a white solid. MS: m/e=369.0 [M+H]+.

Sources & evidence

ORD record
ord-1f1dcbdf2f2146f2b22b769b68127deb
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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