Ethanamine, 2,2,2-trifluoro- → HCID 67157620, compound

HRID 548856Notes

Reaction equation

C(O[C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5])C.[F:27][C:28]([F:32])([F:31])[CH2:29][NH2:30]>>[F:27][C:28]([F:32])([F:31])[CH2:29][NH:30][C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5]

Participants

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-

HCID 42630253HCID 42630253, compound

Product 1

HCID 67157620HCID 67157620, compoundYield 77%

Procedure

As described for example 52, 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (143 mg, 0.4 mmol) was converted, using 2,2,2-trifluoroethylamine instead of ethanolamine, to the title compound (127 mg, 77%) which was obtained as an off-white solid. MS: m/e=411.1 [M+H]+.

Sources & evidence

ORD record: ord-e1a845e9bf404d2c93ca07c810effb4d
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943619B2

Reaction notes

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