Isopropylamine → HCID 42629535, compound

HRID 548857Notes

Reaction equation

C([O:3][C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=O)C.[CH:27]([NH2:30])([CH3:29])[CH3:28]>>[CH:27]([NH:30][C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:3])([CH3:29])[CH3:28]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 42630253HCID 42630253, compound

Product 1

HCID 42629535HCID 42629535, compoundYield 39%

Procedure

As described for example 52, 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (143 mg, 0.4 mmol) was converted, using isopropylamine instead of ethanolamine, to the title compound (58 mg, 39%) which was obtained as a white solid after recrystallisation from heptane:ethyl acetate. MS: m/e=371.0 [M+H]+.

Sources & evidence

ORD record: ord-5659470fe483495db44d26aa4e5ecc13
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943619B2

Reaction notes

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