Cyclopropanemethanamine → HCID 42630131, compound

HRID 548861Notes

Reaction equation

HRID 548861 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=O)C.C(OC(C1N=NC(OCC2[C:41]([C:46]3[CH:51]=[CH:50]C=C(F)C=3)=[N:42]OC=2C)=CC=1)=O)C.NCC1CC1>>[CH:46]1([CH2:41][NH:42][C:4]([C:6]2[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]3[C:15]([C:20]4[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=4)=[N:16][O:17][C:18]=3[CH3:19])=[CH:10][CH:11]=2)=[O:3])[CH2:51][CH2:50]1

Participants

4

Reactant 3

HCID 75646CyclopropanemethanamineHCID 42630252HCID 42630252, compoundHCID 42630253HCID 42630253, compound

Product 1

HCID 42630131HCID 42630131, compoundYield 26%

Procedure

As described for example 50, 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (143 mg, 0.4 mmol), instead of 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester, was converted, using aminomethylcyclopropane instead of methylamine, to the title compound (39 mg, 26%) which was obtained as a white solid. MS: m/e=383.1 [M+H]+.

Sources & evidence

ORD record
ord-539f64d136ef40a385a8c0383b157bea
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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