4-Aminotetrahydropyran → HCID 42630019, compound

Participants

Reaction Steps

As described for example 59, 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (143 mg, 0.4 mmol) was converted, using 4-aminotetrahydropyran instead of aminomethylcyclopropane, to the title compound (120 mg, 73%) which was obtained as a white solid after recrystallization from heptane:ethyl acetate. MS: m/e=413.3 [M+H].

Provenance & Evidence