4-Aminotetrahydropyran → HCID 42630019, compound

HRID 548864Notes

Reaction equation

C(O[C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5])C.[NH2:27][CH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[O:31]1[CH2:32][CH2:33][CH:28]([NH:27][C:4]([C:6]2[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]3[C:15]([C:20]4[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=4)=[N:16][O:17][C:18]=3[CH3:19])=[CH:10][CH:11]=2)=[O:5])[CH2:29][CH2:30]1

Participants

Reactant 2

HCID 4192234-Aminotetrahydropyran

HCID 42630252HCID 42630252, compound

Product 1

HCID 42630019HCID 42630019, compoundYield 73%

Procedure

As described for example 59, 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (143 mg, 0.4 mmol) was converted, using 4-aminotetrahydropyran instead of aminomethylcyclopropane, to the title compound (120 mg, 73%) which was obtained as a white solid after recrystallization from heptane:ethyl acetate. MS: m/e=413.3 [M+H].

Sources & evidence

ORD record: ord-2613ba0ee44f4f4184556ee92a81eb93
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943619B2

Reaction notes

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