Thiomorpholine → HCID 67158094, compound

HRID 548866Notes

Reaction equation

HRID 548866 reaction equation
C(O[C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5])C.[NH:27]1[CH2:32][CH2:31][S:30][CH2:29][CH2:28]1>>[F:26][C:23]1[CH:24]=[CH:25][C:20]([C:15]2[C:14]([CH2:13][O:12][C:9]3[N:8]=[N:7][C:6]([C:4]([N:27]4[CH2:32][CH2:31][S:30][CH2:29][CH2:28]4)=[O:5])=[CH:11][CH:10]=3)=[C:18]([CH3:19])[O:17][N:16]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 67164ThiomorpholineHCID 42630252HCID 42630252, compound

Product 1

HCID 67158094HCID 67158094, compoundYield 85%

Procedure

As described for example 59, 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (143 mg, 0.4 mmol) was converted, using thiomorpholine instead of aminomethylcyclopropane, to the title compound (140 mg, 85%) which was obtained as an off-white solid. MS: m/e=415.4 [M+H]+.

Sources & evidence

ORD record
ord-fdb07f827494462badbd1b3acf524d21
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

Loading…