Ethyl 5-methyl-3-pyridin-4-ylisoxazole-4-carboxylate → (5-Methyl-3-pyridin-2-yl-isoxazol-4-yl)-methanol

HRID 548893Notes

Reaction equation

HRID 548893 reaction equation
C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:8][O:9][C:10]=1[CH3:11])=O)C.C(OC(C1C(C2C=CN=CC=2)=NOC=1C)=O)C>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[C:6]=1[CH2:4][OH:3]

Participants

3

Reactant 2

HCID 22137723Ethyl 5-methyl-3-pyridin-4-ylisoxazole-4-carboxylateHCID 22309063HCID 22309063, compound

Product 1

HCID 66643722(5-Methyl-3-pyridin-2-yl-isoxazol-4-yl)-methanolYield 97%

Procedure

As described for example 67b, 5-methyl-3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester (25 g, 108 mmol) was converted, instead of 5-methyl-3-pyridin-4-yl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (19.8 g, 97%) which was obtained as a light yellow solid. MS: m/e=191.3 [M+H]+.

Sources & evidence

ORD record
ord-fd7fae926a564b38ad959ea6c27fb0a3
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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