5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid ethyl ester → 5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][N:13]=2)=[N:8][O:9][C:10]=1[CH3:11])=[O:5])C.COC(C1C=NC(OCC2C(C3C=CC(Cl)=CC=3)=NOC=2)=CN=1)=O>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][N:13]=2)[C:6]=1[C:4]([OH:5])=[O:3]Participants
3
Procedure
As described for example 112a, 5-methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid ethyl ester (500 mg, 2.1 mmol) was converted, instead of 5-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester, to the title compound (321 mg, 73%) which was obtained as an off white solid. MS: m/e=204.1 [M−H]−.
Sources & evidence
- ORD record
- ord-ffcd96245058420b8628ef546a05141f
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07943619B2
Reaction notes
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