HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid ethyl ester → 5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 67157605 | — |
| Reactant | 5-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester | HCID 67157839 | — |
| Product | 5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid | HCID 67157819 | 74.5% |
Reaction Steps
As described for example 112a, 5-methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid ethyl ester (500 mg, 2.1 mmol) was converted, instead of 5-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester, to the title compound (321 mg, 73%) which was obtained as an off white solid. MS: m/e=204.1 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943619B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-ffcd96245058420b8628ef546a05141f |
| Source note | uspto-grants-2011_05 |