2-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione → C-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methylamine

HRID 548912노트

반응식

HRID 548912 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([CH2:13][N:14]3C(=O)C4C(=CC=CC=4)C3=O)=[C:11]([CH3:25])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.FC1C=CC(C2C(CN3C(=O)C4C(=CC=CC=4)C3=O)=C(C)ON=2)=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([CH2:13][NH2:14])=[C:11]([CH3:25])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 671575752-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dioneHCID 671580562-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione

생성물 1

HCID 67157896C-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methylamine수율 77%

실험 절차

As described for example 78b, 2-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione (6.26 g, 19 mmol) was converted, instead of 2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione, to the title compound (2.95 g, 77%) which was obtained as a yellow oil. MS: m/e=207.3 [M+H]+.

출처 및 근거

ORD 기록
ord-771144c4e4784355b44195322e387285
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943619B2

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