HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione → C-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione | HCID 67157575 | — |
| Reactant | 2-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione | HCID 67158056 | — |
| Product | C-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methylamine | HCID 67157896 | 77% |
Reaction Steps
As described for example 78b, 2-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione (6.26 g, 19 mmol) was converted, instead of 2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione, to the title compound (2.95 g, 77%) which was obtained as a yellow oil. MS: m/e=207.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943619B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-771144c4e4784355b44195322e387285 |
| Source note | uspto-grants-2011_05 |