HCID 67157711, compound → HCID 67157274, compound

HRID 548916Notes

Reaction equation

HRID 548916 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12](CN3C(=O)C4C(=CC=CC=4)C3=O)=[C:11]([CH3:25])[O:10][N:9]=2)=[N:6][CH:7]=1.FC1C=CC([C:33]2C(CN3C(=O)C4C(=CC=CC=4)C3=O)=C(C)O[N:34]=2)=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([NH:34][CH3:33])=[C:11]([CH3:25])[O:10][N:9]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 67157711HCID 67157711, compoundHCID 671580562-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione

Product 1

HCID 67157274HCID 67157274, compoundYield 69%

Procedure

As described for example 78b, 2-[3-(5-chloro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione (1.3 g, 3.68 mmol) was converted, instead of 2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione, to the title compound (570 mg, 69%) which was obtained as a white solid. MS: m/e=224.3 [M+H]+.

Sources & evidence

ORD record
ord-8ed039ca699f488185cd8f2710d0a5e5
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

Loading…