4-Aminotetrahydropyran → HCID 42628907, compound

HRID 548922Notes

Reaction equation

C(O[C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[N:16][O:17][CH:18]=2)=[CH:10][CH:11]=1)=[O:5])C.[NH2:26][CH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[O:30]1[CH2:31][CH2:32][CH:27]([NH:26][C:4]([C:6]2[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]3[C:15]([C:19]4[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=4)=[N:16][O:17][CH:18]=3)=[CH:10][CH:11]=2)=[O:5])[CH2:28][CH2:29]1

Participants

Reactant 2

HCID 4192234-Aminotetrahydropyran

HCID 42630743HCID 42630743, compound

Product 1

HCID 42628907HCID 42628907, compoundYield 82%

Procedure

As described for example 121, 6-[3-(4-fluoro-phenyl)-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (200 mg, 0.58 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (190 mg, 82%) which was obtained as a white solid. MS: m/e=399.1 [M+H]+.

Sources & evidence

ORD record: ord-37595ac4afe344ac82f8160611f723a5
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943619B2

Reaction notes

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