Cyclopropylamine → 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid cyclopropylamide

HRID 548927Notes

Reaction equation

HRID 548927 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:11]([CH2:12][O:13][C:14]2[N:19]=[N:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=2)=[CH:10][O:9][N:8]=1.[CH:23]1([NH2:26])[CH2:25][CH2:24]1>>[CH:23]1([NH:26][C:20]([C:17]2[N:18]=[N:19][C:14]([O:13][CH2:12][C:11]3[C:7]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)=[N:8][O:9][CH:10]=3)=[CH:15][CH:16]=2)=[O:22])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 671581116-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid

Product 1

HCID 426289096-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid cyclopropylamideYield 66%

Procedure

As described for example 123 g, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (70 mg, 0.24 mmol) was converted, using cyclopropylamine instead of isopropylamine, to the title compound (52 mg, 66%) which was obtained as a white solid. MS: m/e=338.4 [M+H]+.

Sources & evidence

ORD record
ord-0b64dcf6522a47a6b6d5789a079c8317
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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