HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid cyclopropylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid | HCID 67158111 | — |
| Product | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid cyclopropylamide | HCID 42628909 | 66% |
Reaction Steps
As described for example 123 g, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (70 mg, 0.24 mmol) was converted, using cyclopropylamine instead of isopropylamine, to the title compound (52 mg, 66%) which was obtained as a white solid. MS: m/e=338.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943619B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-0b64dcf6522a47a6b6d5789a079c8317 |
| Source note | uspto-grants-2011_05 |