Cyclopropanemethanamine → 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid cyclopropylmethyl-amide

HRID 548928Notes

Reaction equation

HRID 548928 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:11]([CH2:12][O:13][C:14]2[N:19]=[N:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=2)=[CH:10][O:9][N:8]=1.[NH2:23][CH2:24][CH:25]1[CH2:27][CH2:26]1>>[CH:25]1([CH2:24][NH:23][C:20]([C:17]2[N:18]=[N:19][C:14]([O:13][CH2:12][C:11]3[C:7]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)=[N:8][O:9][CH:10]=3)=[CH:15][CH:16]=2)=[O:22])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 671581116-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid

Product 1

HCID 426289106-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid cyclopropylmethyl-amideYield 61%

Procedure

As described for example 123 g, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (70 mg, 0.24 mmol) was converted, using aminomethylcyclopropane instead of isopropylamine, to the title compound (50 mg, 61%) which was obtained as an off white solid. MS: m/e=352.3 [M+H]+.

Sources & evidence

ORD record
ord-f19dc34aa4e74436a573497e5c762bd2
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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