HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanamine → 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid cyclopropylmethyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid | HCID 67158111 | — |
| Product | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid cyclopropylmethyl-amide | HCID 42628910 | 61% |
Reaction Steps
As described for example 123 g, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (70 mg, 0.24 mmol) was converted, using aminomethylcyclopropane instead of isopropylamine, to the title compound (50 mg, 61%) which was obtained as an off white solid. MS: m/e=352.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943619B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-f19dc34aa4e74436a573497e5c762bd2 |
| Source note | uspto-grants-2011_05 |