反应详情

To a well stirred suspension of 7-methoxy-2-methylbenzo[b]furan-4-carboxylic acid (from step 4) (4.5 g, 24.21 mmol) and powdered potassium carbonate (7.5 g, 54.61 mmol) in acetone (740.0 mL) was added dimethyl sulfate (4.1 g, 32.76 mmol) and refluxed for 2-3 hours. Reaction mixture was cooled to room temperature and water (500 mL) was added to it. The organic material separated was extracted with ethyl acetate (3×100 ml). The combined organic layers were washed with water ((2×100 mL) and dried over anhydrous sodium sulfate. Removal of solvent under vacuo gave product (4.0 g) as brown viscous oil.

1. temperaturerefluxed for 2-3 hours
2. customReaction mixture
3. customThe organic material separated
4. extractionwas extracted with ethyl acetate (3×100 ml)
5. washThe combined organic layers were washed with water ((2×100 mL)
6. dry with materialdried over anhydrous sodium sulfate
7. customRemoval of solvent under vacuo