反应详情

温度

5 °C

To a suspension of 7-cyclopentyloxy-2-methylbenzo[b]furan-4-carboxylic acid (40.0 g, 0.153 moles) and potassium carbonate (42.0 g, 0.184) in acetone (400 mL) added dimethyl sulfate (24.0 g, 0.307 moles) and refluxed for 4-5 hrs. acetone (305 mL) was distilled off and reaction mixture was cooled to 5° C., ice cold water (500 mL) was and the solid separated was filtered, washed with water (2×100 mL) and dried to get off white solid (43.0 g).

1. temperaturerefluxed for 4-5 hrs
2. distillationacetone (305 mL) was distilled off
3. customreaction mixture
4. customthe solid separated
5. filtrationwas filtered
6. washwashed with water (2×100 mL)
7. customdried