反应详情

The mercaptoethansulphonic acid coming out from the column, in aqueous solution, under nitrogen stream and at pH=1, is simultaneously added with the stoichiometrical amount of L-ornithine (0.64 g) freed from the hydrochloride through Kastel A 300 resin, in aqueous solution and under nitrogen stream. The addition is carried out at pH values of between 6 and 7. Upon the salification is completed the pH of the solution must be of between 5 and 6. The solution is concentrated to about dryness giving place to a colorless oil which is hot taken with 10 ml of 99% methanol. A conversion to white crystal takes place and the mixture is filtered and dried in oven under vacuum 1.117 g; yield 85%; m.p. 187°-192° C; the pH in 10% aqueous solution is 4.2 and solubility in water is perfect. The analysis gave the following results:

1. additionThe addition
2. concentrationThe solution is concentrated to about dryness
3. customgiving place to a colorless oil which
4. filtrationthe mixture is filtered
5. customdried in oven under vacuum 1.117 g
6. customThe analysis gave the
7. customfollowing results