2-Amino-2-methyl-1,3-propanediol → HCID 10199661, compound

HRID 549011Notes

Reaction equation

HRID 549011 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11](O)=[O:12])=[CH:8][CH:9]=2)[C:4]([C:14]2[NH:22][C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[CH:15]=2)=[CH:3]1.[NH2:23][C:24]([CH3:29])([CH2:27][OH:28])[CH2:25][OH:26]>>[OH:26][CH2:25][C:24]([NH:23][C:11]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:2]([CH3:1])[CH:3]=[C:4]2[C:14]1[NH:22][C:17]2=[N:18][CH:19]=[CH:20][CH:21]=[C:16]2[CH:15]=1)=[O:12])([CH2:27][OH:28])[CH3:29]

Participants

3

Reactant 2

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 22477444HCID 22477444, compound

Product 1

HCID 10199661HCID 10199661, compound

Procedure

By proceeding in a manner similar to Example 14(a) above but using 1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxylic acid [Example 15(d)] and 2-amino-2-methyl-1,3-propanediol, there was prepared 1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-arboxylic acid (2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-amide as a yellow solid, m.p. 180-182° C. MS: 379 (MH+).

Sources & evidence

ORD record
ord-933fea2a683643b4b74069eba8338d7f
Source dataset
uspto-grants-2011_05
Patent number
US07943616B2

Reaction notes

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