Water → HCID 22477321, compound

HRID 549023Notes

Reaction equation

HRID 549023 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][N:18]=[C:13]3[C:12]=2[CH2:20][CH2:21][CH2:22][NH2:23])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:24]([N:27]=[C:28]=[O:29])[CH2:25][CH3:26].O>O1CCCC1>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][N:18]=[C:13]3[C:12]=2[CH2:20][CH2:21][CH2:22][NH:23][C:28]([NH:27][CH2:24][CH2:25][CH3:26])=[O:29])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 962WaterHCID 61033Propyl isocyanateHCID 22477209HCID 22477209, compound

Product 1

HCID 22477321HCID 22477321, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-(6-(4-tert-butylphenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)propylamine (0.0324 mmol) [Example 35] in tetrahydrofuran (2 mL) was treated with n-propyl-isocyanate (0.0324 mmol). The solution was stirred at room temperature for 12 hours and then treated with water (3 mL). The resulting precipitate was filtered, then washed with water and then dried under vacuum at 50° C. to give the title compound as a beige solid. MS: 394 (MH+). HPLC (Method C): RT=3.25 minutes.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with water
  3. customdried under vacuum at 50° C.

Sources & evidence

ORD record
ord-0a0d93f04eba4add81d12eb9a3298ad1
Source dataset
uspto-grants-2011_05
Patent number
US07943616B2

Reaction notes

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