Ammonia → HCID 67158185, compound

HRID 549232Notes

Reaction equation

HRID 549232 reaction equation
Cl[C:2]1[C:11]2=[N:12][N:13]([CH2:16][CH2:17][CH3:18])[C:14]([CH3:15])=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[NH3:19]>CO>[CH3:15][C:14]1[N:13]([CH2:16][CH2:17][CH3:18])[N:12]=[C:11]2[C:10]=1[C:9]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:3]=[C:2]2[NH2:19]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11842676HCID 11842676, compound

Product 1

HCID 67158185HCID 67158185, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
150 °C

Procedure

A Parr vessel was charged with 4-chloro-1-methyl-2-propyl-2H-pyrazolo[3,4-c]quinoline (4.31 g) and a solution of ammonia in methanol (50 mL of 7 N). The reaction was heated at 150° C. for 24 hours and allowed to cool to room temperature. Most of the methanol was removed under reduced pressure, and water was added. A precipitate formed and was isolated by filtration, washed with water, and dried on the vacuum filter funnel to provide 3.8 g of 1-methyl-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine as a white solid.

Workup

  1. temperatureto cool to room temperature
  2. customMost of the methanol was removed under reduced pressure, and water
  3. additionwas added
  4. customA precipitate formed
  5. customwas isolated by filtration
  6. washwashed with water
  7. customdried on the vacuum
  8. filtrationfilter funnel

Sources & evidence

ORD record
ord-fb699a164a3f46938d34f537a89fec8d
Source dataset
uspto-grants-2011_05
Patent number
US07943636B2

Reaction notes

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