Hydrochloric Acid → HCID 67158191, compound

Participants

Reaction Conditions

Reaction Steps

Hydrochloric acid (0.55 mL of 6 M) was added to a suspension of tert-butyl 4-[(4-bromo-5-cyano-2-methyl-2H-pyrazol-3-yl)methyl]-4-fluoropiperidine-1-carboxylate (446 mg, 1.11 mmol) in ethanol (10 mL), and the reaction was heated at 70° C. for 1.5 hours, allowed to cool to room temperature, and concentrated under reduced pressure to provide 4-bromo-5-[(4-fluoropiperidin-4-yl)methyl]-1-methyl-1H-pyrazole-3-carbonitrile hydrochloride as a white solid.

Provenance & Evidence