Hydrochloric Acid → HCID 67158191, compound

HRID 549255Notes

Reaction equation

HRID 549255 reaction equation
[ClH:1].[Br:2][C:3]1[C:7]([C:8]#[N:9])=[N:6][N:5]([CH3:10])[C:4]=1[CH2:11][C:12]1([F:25])[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1>C(O)C>[ClH:1].[Br:2][C:3]1[C:7]([C:8]#[N:9])=[N:6][N:5]([CH3:10])[C:4]=1[CH2:11][C:12]1([F:25])[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67157790HCID 67157790, compound

Product 1

HCID 67158191HCID 67158191, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

Hydrochloric acid (0.55 mL of 6 M) was added to a suspension of tert-butyl 4-[(4-bromo-5-cyano-2-methyl-2H-pyrazol-3-yl)methyl]-4-fluoropiperidine-1-carboxylate (446 mg, 1.11 mmol) in ethanol (10 mL), and the reaction was heated at 70° C. for 1.5 hours, allowed to cool to room temperature, and concentrated under reduced pressure to provide 4-bromo-5-[(4-fluoropiperidin-4-yl)methyl]-1-methyl-1H-pyrazole-3-carbonitrile hydrochloride as a white solid.

Workup

  1. temperatureto cool to room temperature
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-0ed57bf28f604d96b28adfff074b636c
Source dataset
uspto-grants-2011_05
Patent number
US07943636B2

Reaction notes

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