2-Chloro-4-fluorobenzene-1-sulfonyl chloride → 1-(2-Chloro-4-fluoro-benzenesulfonyl)-4-piperazin-1-yl-1H-pyrrolo[3,2-c]pyridine Hydrochloride

HRID 549312Notes

Reaction equation

HRID 549312 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[NH:13]1[C:21]2[CH:20]=[CH:19][N:18]=[C:17]([N:22]3[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]3)[C:16]=2[CH:15]=[CH:14]1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([N:13]1[C:21]2[CH:20]=[CH:19][N:18]=[C:17]([N:22]3[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]3)[C:16]=2[CH:15]=[CH:14]1)(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 5228462-Chloro-4-fluorobenzene-1-sulfonyl chlorideHCID 671567091-Piperazinecarboxylic acid,4-(1h-pyrrolo[3,2-c]pyridin-4-yl)-,1,1-dimethylethyl ester

Product 1

HCID 671568631-(2-Chloro-4-fluoro-benzenesulfonyl)-4-piperazin-1-yl-1H-pyrrolo[3,2-c]pyridine Hydrochloride

Procedure

2-Chloro-4-flourobenzenesulfonyl chloride (29.5 mg) was added to tert-butyl 4-(1H-pyrrolo[3,2-c]pyridin-4-yl)piperazine-1-carboxylate the title compound (2.4 mg). LC/MS RT: 1.361 (System 10 till 40% MeCN over 1.5 min, ACE C8), Purity. 90%. MS: 396 (M+1)

Sources & evidence

ORD record
ord-9b587cdd9cdc48659ff5311b99eedca3
Source dataset
uspto-grants-2011_05
Patent number
US07943639B2

Reaction notes

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