Phenylmethanesulfonyl chloride → 1-Phenylmethanesulfonyl-4-piperazin-1-yl-1 H-pyrrolo[3,2-c]pyridine Hydrochloride

HRID 549313Notes

Reaction equation

HRID 549313 reaction equation
[C:1]1([CH2:7][S:8]([Cl:11])(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:12]1[C:20]2[CH:19]=[CH:18][N:17]=[C:16]([N:21]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)[C:15]=2[CH:14]=[CH:13]1>>[ClH:11].[C:1]1([CH2:7][S:8]([N:12]2[C:20]3[CH:19]=[CH:18][N:17]=[C:16]([N:21]4[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]4)[C:15]=3[CH:14]=[CH:13]2)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 74740Phenylmethanesulfonyl chlorideHCID 671567091-Piperazinecarboxylic acid,4-(1h-pyrrolo[3,2-c]pyridin-4-yl)-,1,1-dimethylethyl ester

Product 1

HCID 671575101-Phenylmethanesulfonyl-4-piperazin-1-yl-1 H-pyrrolo[3,2-c]pyridine Hydrochloride

Procedure

Phenyl-methanesulfonyl chloride (24.6 mg) was added to tert-butyl 4-(1H-pyrrolo[3,2-c]pyridin-4-yl)piperazine-1-carboxylate the title compound (0.2 mg). LC/MS RT: 1.007 (System 10 till 40% MeCN over 1.5 min, ACE C8), Purity. 90%. MS: 357 (M+1).

Sources & evidence

ORD record
ord-7bec195fb1ab4e15bf6f7aecf9a587fe
Source dataset
uspto-grants-2011_05
Patent number
US07943639B2

Reaction notes

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