5-Chlorothiophene-2-sulfonyl chloride → 1-(5-Chloro-thiophene-2-sulfonyl)-4-piperazin-1-yl-1H-pyrrolo[3,2-c]pyridine Hydrochloride

HRID 549314Notes

Reaction equation

HRID 549314 reaction equation
[Cl:1][C:2]1[S:6][C:5]([S:7](Cl)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[NH:11]1[C:19]2[CH:18]=[CH:17][N:16]=[C:15]([N:20]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)[C:14]=2[CH:13]=[CH:12]1>>[ClH:1].[Cl:1][C:2]1[S:6][C:5]([S:7]([N:11]2[C:19]3[CH:18]=[CH:17][N:16]=[C:15]([N:20]4[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]4)[C:14]=3[CH:13]=[CH:12]2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27339255-Chlorothiophene-2-sulfonyl chlorideHCID 671567091-Piperazinecarboxylic acid,4-(1h-pyrrolo[3,2-c]pyridin-4-yl)-,1,1-dimethylethyl ester

Product 1

HCID 671570701-(5-Chloro-thiophene-2-sulfonyl)-4-piperazin-1-yl-1H-pyrrolo[3,2-c]pyridine Hydrochloride

Procedure

5-Chlorothiophene-2-sulfonyl chloride (28.0 mg) was added to tert-butyl 4-(1H-pyrrolo[3,2-c]pyridin-4-yl)piperazine-1-carboxylate the title compound (7.2 mg). LC/MS RT: 1.381 (System 10 till 40% MeCN over 1.5 min, ACE C8), Purity. 97%. MS: 483 (M+1).

Sources & evidence

ORD record
ord-c097be5a34dd425a8482371f0ecea297
Source dataset
uspto-grants-2011_05
Patent number
US07943639B2

Reaction notes

Loading…