2-Amino-1-(4-fluorophenyl)ethanone → (RS)-2-{[2-(4-Fluoro-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-piperidine-1-carboxylic acid tert butyl ester

HRID 549335Notes

Reaction equation

HRID 549335 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]([OH:17])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:18][CH2:19][C:20]([C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=[O:21]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15](=[O:17])[NH:18][CH2:19][C:20]([C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=[O:21])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 15811772-Amino-1-(4-fluorophenyl)ethanoneHCID 50585361-Boc-2-Piperidineacetic Acid

Product 1

HCID 86629006(RS)-2-{[2-(4-Fluoro-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-piperidine-1-carboxylic acid tert butyl esterYield 61.9%

Procedure

The title compound (0.77 g) was prepared from 2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (0.80 g) and 2-amino-1-(4-fluoro-phenyl)-ethanone (0.63 g) according to the method of description 20.

Sources & evidence

ORD record
ord-8d16db9be8cb4d27a93b9057338d1087
Source dataset
uspto-grants-2011_05
Patent number
US07943645B2

Reaction notes

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