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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 549335Generated: October 25, 2026

2-Amino-1-(4-fluorophenyl)ethanone → (RS)-2-{[2-(4-Fluoro-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-piperidine-1-carboxylic acid tert butyl ester

https://huagongshe.com/reaction/549335

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-1-(4-fluorophenyl)ethanoneHCID 1581177—
Reactant1-Boc-2-Piperidineacetic AcidHCID 5058536—
Product(RS)-2-{[2-(4-Fluoro-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-piperidine-1-carboxylic acid tert butyl esterHCID 8662900661.9%

Reaction Steps

The title compound (0.77 g) was prepared from 2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (0.80 g) and 2-amino-1-(4-fluoro-phenyl)-ethanone (0.63 g) according to the method of description 20.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07943645B2
Source datasetuspto-grants-2011_05
ORD IDord-8d16db9be8cb4d27a93b9057338d1087
Source noteuspto-grants-2011_05