1-Benzyl-2-(bromomethyl)piperidine → (RS)-1-Benzyl-2-[3-(4-fluoro-phenyl)-pyrazol-1-ylmethyl]-piperidine

HRID 549346Notes

Reaction equation

HRID 549346 reaction equation
Br[CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][N:4]1[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:27]=[CH:26][NH:25][N:24]=2)=[CH:19][CH:18]=1>>[CH2:9]([N:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH:3]1[CH2:2][N:25]1[CH:26]=[CH:27][C:23]([C:20]2[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=2)=[N:24]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 231462741-Benzyl-2-(bromomethyl)piperidineHCID 178505519HCID 178505519, compound

Product 1

HCID 67158941(RS)-1-Benzyl-2-[3-(4-fluoro-phenyl)-pyrazol-1-ylmethyl]-piperidineYield 22.9%

Procedure

The title compound (0.8 g) was prepared from 2-bromomethyl-N-benzylpiperidine (2.68 g) and 3-(4-fluoro-phenyl)-1H-pyrazole (1.62 g) according to the method of example 93.

Sources & evidence

ORD record
ord-d0b4690d4f224372956414d06587cb39
Source dataset
uspto-grants-2011_05
Patent number
US07943645B2

Reaction notes

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