反应详情

3-[4-(4-Fluorophenyl)-1H-imidazol-2-ylmethyl]-4-{1-[5-(4-fluorophenyl)-2-methylthiazol-4-yl]-methanoyl}-piperazine-1-carboxylic acid tert-butyl ester description 112 (0.130 g) was dissolved in TFA and stirred under argon at room temperature for 3 hours. The TFA was evaporated and the residue chromatographed over silica gel, eluting with a gradient of 0 to 10% [9:1 methanol/conc. ammonia solution] in dichloromethane. The title compound was obtained as a white foam (0.095 g), mass spectrum (API+) 480 [MH+], C25H23F2N5OS requires 479.

1. customThe TFA was evaporated
2. customthe residue chromatographed over silica gel
3. washeluting with a gradient of 0 to 10% [9:1 methanol/conc. ammonia solution] in dichloromethane