反应详情

A mixture of 2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile (10 g), hydrazine monohydrate (2.4 ml) and acetic acid (5.2 ml) in dry benzene (100 ml) was refluxed for 4 hours. The reaction mixture was cooled and extracted with 3N-hydrochloric acid (80 ml×3). The extracts were concentrated in vacuo to 100 ml of the volume and the solution was neutralized with aqueous ammonia solution. The separated solid was collected, washed with water and dried to give 5-amino-4-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazole (2.02 g).

1. temperaturewas refluxed for 4 hours
2. temperatureThe reaction mixture was cooled
3. extractionextracted with 3N-hydrochloric acid (80 ml×3)
4. concentrationThe extracts were concentrated in vacuo to 100 ml of the volume
5. customThe separated solid was collected
6. washwashed with water
7. customdried