Hydrochloric Acid → 2-(4-Fluorophenyl)-3-(pyridin-4-yl)4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride

HRID 54942Notes

Reaction equation

HRID 54942 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[C:11]3[NH:12][CH2:13][CH2:14][CH2:15][N:10]3[N:9]=2)=[CH:4][CH:3]=1.[ClH:23]>CO>[ClH:23].[ClH:23].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[C:11]3[NH:12][CH2:13][CH2:14][CH2:15][N:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1355153842-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

Product 1

HCID 1363784152-(4-Fluorophenyl)-3-(pyridin-4-yl)4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (100 mg) in methanol (2 ml) was added 10% methanolic hydrogen chloride (0.5 ml). The resulting clear solution was concentrated in vacuo. To the residue was added ethanol (3 ml) and the solution was concentrated in vacuo. The residue was crystallized from a mixture of ethanol and diethyl ether to give 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride (100 mg).

Workup

  1. concentrationThe resulting clear solution was concentrated in vacuo
  2. additionTo the residue was added ethanol (3 ml)
  3. concentrationthe solution was concentrated in vacuo
  4. customThe residue was crystallized from a mixture of ethanol and diethyl ether

Sources & evidence

ORD record
ord-74b0c6cafdd747a88b5d591665edad9a
Source dataset
uspto-grants-1997_04
Patent number
US05624931

Reaction notes

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