Acetic Anhydride → Phenol, 3-bromo-, 1-acetate

HRID 549458Notes

Reaction equation

HRID 549458 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[C:16](OC(=O)C)(=[O:18])[CH3:17]>ClCCl>[C:16]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)(=[O:18])[CH3:17]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 115633-Bromophenol

Product 1

HCID 141946Phenol, 3-bromo-, 1-acetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-bromophenol was dissolved in dichloromethane. Triethylamine (1 eq) and acetic anhydride (2 eq) were added and the mixture was stirred at room temperature for 5 hours. The solvent was eliminated by vacuum evaporation. The evaporation residue was taken up in dichloromethane then dried on magnesium sulfate. The solvent was eliminated by vacuum evaporation.

Workup

  1. customThe solvent was eliminated by vacuum evaporation
  2. customthen dried on magnesium sulfate
  3. customThe solvent was eliminated by vacuum evaporation

Sources & evidence

ORD record
ord-c3f819f3a0024960afb0483057812f8b
Source dataset
uspto-grants-2011_05
Patent number
US07943661B2

Reaction notes

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