反应详情

To a solution of 2-(4-methylthiophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (190 mg) in dichloromethane (6 ml) was added m-chloroperbenzoic acid (127 mg) under ice cooling. The mixture was stirred at ambient temperature for 30 minutes and diluted with dichloromethane. The solution was washed with an aqueous saturated sodium thiosulfate solution, an aqueous saturated sodium bicarbonate solution and brine, dried and concentrated in vacuo. The residue was purified by column chromatography on silica gel and the obtained crude solid was recrystallized from a mixture of 2-propanol and ether to give 2-(4-methylsulfinylphenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (168 mg).

1. washThe solution was washed with an aqueous saturated sodium thiosulfate solution
2. dry with materialan aqueous saturated sodium bicarbonate solution and brine, dried
3. concentrationconcentrated in vacuo
4. customThe residue was purified by column chromatography on silica gel
5. customthe obtained crude solid
6. customwas recrystallized from a mixture of 2-propanol and ether