2-(4-Fluorophenyl)-3-(pyridin-4-yl)4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride → 2-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride

HRID 54953Notes

Reaction equation

HRID 54953 reaction equation
[ClH:1].Cl.[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:13]3[NH:14][CH2:15][CH2:16][CH2:17][N:12]3[N:11]=2)=[CH:6][CH:5]=1>C(O)(C)C>[ClH:1].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:13]3[NH:14][CH2:15][CH2:16][CH2:17][N:12]3[N:11]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 1363784152-(4-Fluorophenyl)-3-(pyridin-4-yl)4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride

Product 1

HCID 1363784182-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochlorideYield 110.4%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride (183 mg) was dissolved in hot aqueous isopropyl alcohol solution 15.5 ml). The solution was cooled and the separated solid was collected, washed with isopropyl alcohol and dried to give 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride 182 mg).

Workup

  1. temperatureThe solution was cooled
  2. customthe separated solid was collected
  3. washwashed with isopropyl alcohol
  4. customdried

Sources & evidence

ORD record
ord-e8b254eff7f84b2c891201bd71d84dd1
Source dataset
uspto-grants-1997_04
Patent number
US05624931

Reaction notes

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